Continuous
It looks like you only need 2d curl, so let's start with a simpler continuous definition:
$$ \omega = \nabla \times \mathbf{u} = \frac{\delta v}{\delta x} - \frac{\delta u}{\delta y}
$$
where 2d vector field $\mathbf{u}=(u,v)$ (same as your $\mathbf F = (F_1,F_2,F_3)$, dropping $F_3$). Note that curl is a vector and in the 2d version, and is purely in the z direction, and is customarily written as a scalar.
Discretization
We'll assume $(u,v)$ is sampled on a grid (i.e. at "vertices", where lines cross, and indices have integer values), with spacing $\Delta x$ and $\Delta y$ (equal for a square grid, but helps "typecheck" the discretization).
Forward differences
The simplest Finite Difference discretization method is forward differences:
$$
\omega_{i,j} = \frac{ v_{i+1,j} - v_{i,j} }{ \Delta x } - \frac{ u_{i,j+1}-u_{i,j} }{ \Delta y }
$$
Central differences
But central differences is more accurate (note the 2 in the denominator, because we're discretizing over 2 grid cells):
$$
\omega_{i,j} = \frac{ v_{i+1,j} - v_{i-1,j} }{ 2\Delta x } - \frac{ u_{i,j+1}-u_{i,j-1} }{ 2\Delta y }
$$
Finer central differences
If you look again at the first forward differences method, you'll see it's the same as central differences, just for $\omega_{i+\frac{1}{2},j+\frac{1}{2}}$ instead of $\omega_{ i,j}$. EDIT Actually not, because the central differences are for different locations: the first for $\omega_{i+\frac{1}{2},j}$ and the second for $\omega_{i,j+\frac{1}{2}}$. Instead, for each term, we can average the other co-ordinate values to interpolate the center. That is,
$$
\omega_{i+\frac{1}{2},j+\frac{1}{2}} = \frac{
\frac{ v_{i+1,j} - v_{i,j} }{ \Delta x } + \frac{ v_{i+1,j+1} - v_{i,j+1} }{ \Delta x }
}{2}
- \frac{
\frac{ u_{i,j+1}-u_{i,j} }{ \Delta y } + \frac{ u_{i+1,j+1}-u_{i+1,j} }{ \Delta y }
}{2}
$$
At this point, the advantages of the Calculus of Finite Differences (in Philip Roe's answer) become stark. The above is:
$$
\omega_{i+\frac{1}{2},j+\frac{1}{2}} = \mu_y \delta_x v_{i,j} - \mu_x \delta_y u_{i,j}
$$
Let me unpack that first term: the $\mu_y$ averages over values at $j$ and $j+1$ in y-direction (i.e. the two expressions divided by $2$), the $\delta_x$ is the difference between values at $i$ and $i+1$ in x-direction (i.e. each of the aforementioned expressions, which are divided by $\Delta x$). I'm not sure what happens to the $\Delta x$; I think the idea is to let $\Delta x=1$, so it can be ignored.
Or (if you're better than me at remembering how the offset indices go) just:
$$
\omega = \mu_y \delta_x v - \mu_x \delta_y u
$$
These seem what you're going for with your $\nabla_1$ and $\nabla_2$.
EDIT Now I think you're going for finite differences along diagonal lines for your $\nabla_2$ (the corners of a square). IDK, but I think that would work, but you'd need to calculate $(u,v)$ perpendicular to each diagonal, and also adjust the lengths that you're dividing by (though I guess the wikipedia integral version may take care of this, since it uses area, not lengths). Of course, like the above, it would be for the center of a cell, $\omega_{ i+\frac{1}{2},j+\frac{1}{2} }$, rather than at the data points.
Accuracy
I won't go into it here, but the accuracy of the above Finite Difference methods is usually analysed with Taylor Series. Forward differences is first order $O(\Delta x)$, central differences is second order $O( \Delta x^2 )$.