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What scientific problems can be simulated with computers that couldn’t be simulated 10 years ago?

I’m particularly interested in cutting-edge scientific simulations, which wouldn’t have been possible (due to computational constraints, or lack of knowledge) 10 years ago.

Please provide links to software, if possible.

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This report on exascale computing from the DOE might be useful: https://science.energy.gov/~/media/ascr/ascac/pdf/reports/Exascale_subcommittee_report.pdf

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