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As of today (31-Jul-21), you can use the solver MAiNGO It has a python interface. Install it with: pip install maingopy Bongartz, Dominik; Mitsos, Alexander, Deterministic global optimization of process flowsheets in a reduced space using McCormick relaxations, J. Glob. Optim. 69, No. 4, 761-796 (2017). ...

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